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Prevalence of urinary tract infection and antibiotic sensitivity among pregnant women having prenatal check-up at a tertiary hospital in manila

Raissa Marie M. Tud, MD and Martha Millar-Aquino, MD, FPOGS
Department of Obstetrics and Gynecology, Ospital ng Maynila Medical Center

Objective: The objective of this study is to determine the prevalence and the most common causative agent of urinary tract infection (UTI) in pregnant women having prenatal check-up at a tertiary hospital, as well as the antibiotic sensitivity of these organisms to selected antimicrobials that are currently recommended for use in the treatment of UTI in pregnancy (specifically Nitrofurantoin, Amoxicillin, Cephalexin, Cefuroxime, Amoxicillin with Clavulanic acid). The results of this study will not only update the hospital’s biogram, it will also aid the physicians in prescribing patients with the most cost-effective regimen.

Methodology: Patients seen at the outpatient department were included in the study starting May 2017 up to September 2017. Patients with previous antibiotic intake during the current pregnancy were excluded. A questionnaire containing demographic data, prenatal history, checklist for symptoms, and consent were provided for each patient. As per guidelines, urine gram stain and culture studies were requested during their prenatal visit. All urine specimen were sent to the same laboratory for microscopy and culture. Results were analyzed using SPSS v 23.0

Result: The prevalence of urinary tract infection in pregnant patients having prenatal care at a tertiary hospital in Manila was 15.6%. The most common isolates were still E. coli and Staphylococcus. Symptoms were not reflective of the presence of UTI and previous prenatal care did not affect the presence UTI. Analysis of sensitivity and resistance patterns of the isolated organisms showed increasing resistance to the commonly used antibiotics given to pregnant patients, especially Co-Amoxiclav. Cephalosporins, on the other hand, remain to have good sensitivity.

Conclusion: Urinary tract infection is prevalent among pregnant women having prenatal check up at a tertiary hospital. It is recommended that guidelines on the diagnosis of UTI in pregnancy be strictly followed so that management will be culture-guided, thus preventing the development of antibiotic resistance.