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High grade ovarian serous carcinoma associated with chronic schistosomiasis

Shiara Marriz T. Marquez, MD; Jennifer T. Co, MD, FPOGS, FPIDSOG and Lylah D. Reyes, MD, MSc, FPOGS
Department of Obstetrics and Gynecology, Far Eastern University - Nicanor Reyes Medical Foundation Medical Center

Schistosomiasis has been established as a causative factor in urinary bladder, liver, colorectal and cervical cancer. However, its role in ovarian malignancy has not been described. With the premise that long-standing inflammation secondary to chronic infection predisposes to cancer by promoting an environment that cultivates genomic lesions and tumor initiation, we are left with an open question: Does chronic infection with schistosomiasis also predispose to ovarian cancer? In this paper, we presented a case of a 54-year-old diagnosed with high grade serous carcinoma of the ovary and fallopian tube with a history of chronic infection with Schistosomiasis. In this case, the infection caused neoplastic lesions in the right fallopian tube with subsequent seeding of malignant cells to the right ovary, indirectly causing the high grade serous ovarian carcinoma of the patient.