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Angiomyofibroblastoma of the vulva: A diagnostic dilemma

Katrina D. Romblon, MD and Rex Marco M. Poblete, MD, FPOGS, FPSUOG
Department of Obstetrics and Gynecology, De La Salle University Medical Center

Angiomyofibroblastoma (AMFB) is a rare, benign, well-circumscribed mesenchymal soft tissue neoplasm redominantly occurring in the vulvovaginal region among women of reproductive age (35-45 years old). Histologically, it is characterized by presence of alternating hypo and hypercellular areas containing spindle and round stromal cells admixed with blood vessels. At present, there are 137 cases reported since it was first described in 1992. Currently, there are no published cases of Angiomyofibroblastoma in the Philippines. This is a case report of a 31 year old, nulligravid patient who presented with unilateral labial enlargement which was noted to be painless and slow growing. The initial impression was that of a benign tumor of the labia. The mass was excised and histopathologic results were consistent with the microscopic findings of Angiomyofibroblastoma. Simple excision of the mass is the only treatment, as in this case, and is noted to have extremely low rate of recurrence.

The clinical importance to distinguish this unusual neoplasm from Aggressive Angiomyxoma and other mesenchymal malignant neoplasm with metastatic potential should be emphasized for appropriate management.