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Colloid carcinoma of the cervix and endometrial adenocarcinoma: A case report of collision tumor

Ali Anjelica Uy-Abuan, MD and Maria Lora C. Tupas, MD, FPOGS, FSGOP
Department of Obstetrics and Gynecology, West Visayas State University Medical Center

Background: Collision tumors are defined by the co-existence of two or more tumors in the same or adjacent organs which are topographically and histologically distinct with minimal or no histological admixture. Collision tumors are rare but some have been reported in other organs, as well as the female genital tract.

Objectives: To define and explain the pathogenesis, histogenesis and management; as well as present previously reported collision tumors in different countries as well as in our local setting.

Clinical case: This is a rare case of a 68-year-old nulligravid who complained of postmenopausal bleeding. Imaging studies revealed a uterine mass. Differential diagnosis non-neoplastic conditions and benign and malignant neoplasms. Radical Modified hysterectomy with bilateral salpingo-oophorectomy with frozen section and complete staging was performed. Histopathology revealed a coexistence of a colloid carcinoma of the cervix and endometrial adenocarcinoma.

Conclusion: Collision Tumors are infrequent neoplasias, there are few reports about them in medical literature. Colloid carcinoma of the cervix is a rare subtype and few studies are reported in literature. Their prognosis is unknown since there are no previous similar cases. Colloid carcinomas present a histologic as well as clinical dilemma. Their histogenetic origin remains controversial and their rarity precludes determination of the best treatment options to improve survival outcomes.