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Androgen insensitivity syndrome (AIS)

Diana Iskandar, MD; Anna Belen I. Alensuela, MD, FPOGS, FPSREI
Department of Obstetrics and Gynecology, Jose R. Reyes Memorial Medical Center

Androgen Insensitivity Syndrome (AIS) is a rare condition, it is an X-linked-mutation that is considered as a disease caused by resistance of androgen receptor to its actions. It is expressed in a variety of phenotypes ranging from male infertility to completely normal female external genitalia. This is a case of a 25 year-old with Complete Androgen Insensitivity Syndrome (CAIS), presented as phenotypical female with secondary sexual development, bilateral inguinal masses. Gonadectomy, estrogen replacement therapy and psychological support are part of long term management.